Model Question Paper MPharm Teerthanker Mahaveer College of Pharmacy : www.tmu.ac.in

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Teerthanker Mahaveer College of Pharmacy
M.PHARM. I SEMESTER EXAMINATION 2010-11
Course Code: MPG101 Paper ID: 0123104
Evaluation of Drugs
Time: 3 Hours Max. Marks: 75

Model Question List : http://www.tmu.ac.in/oldquestions.htm
Model Question Paper : http://www.tmu.ac.in/pdf/oldquestionMpharm201011.pdf

Note: Attempt six questions in all. Q. No. 1 is compulsory.
1. Answer any five of the following (limit your answer in 50 words). (3x5=15)
a) Predict the number of signals and splitting of signals for the proton NMR spectra of 1-methylcyclopropane.
b) Explain metastable peak.
c) How will you differentiate between acetophenone and acetamide on the basis of their IR spectra?
d) Enlist microorganisms present in crude drugs.
e) Give the principle involved in the biological test of the living contaminants in vaccines.
f) Give the formula for the screening of anti-inflammatory activity by paw-edema method.
g) Enlist various parameters for standardization of crude drugs.
h) Give the principle involved in the screening of diuretic activity.

2. Discuss the factors affecting coupling constant. Comment on the importance of UV for the structure elucidation of phyto-constituents giving suitable examples. (12)

3. Write notes on: (6x2=12)
a) Identification of aflatoxins crude drugs.
b) Determination of microorganisms in crude drugs.

4. Discuss the principle and procedures of microtomy and histological techniques. (12)

5. Give the principle and methodology of different models for the determination of antioxidant activity.

6. Write notes on: (6x2=12)
a) Screening of hepatoprotective activity.
b) Screening of anticancer activity.

7. What do you understand by the term Biomarkers? Discuss its significance in the standardization of crude drugs with suitable examples. (12)

8. Example the term stability of natural products. Discuss the methodology involved for the stability testing of natural products. (12)