www.binc.scisjnu.ernet.in BINC Exam 2012 Question Paper : BioInformatics National Certification

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BioInformatics National Certification (BINC) Examination
Sample paper for BINC :
SHORT TYPE : PAPER II

BIOINFORMATICS : (40%)
1. a) What do you understand by sensitivity and specificity in BLAST? (3)
b) Suppose in a BLAST search you got an E-value of about 2 x 10 -10. What does this E value mean? Name two parameters that determine the E-value. (4)
c) Briefly explain the major differences between BLAST method and PSIBLAST method. (3)

2. a) What is dynamic programming algorithm? (2)
b) What is the basic difference between Needleman-Wunsch and Smith- Waterman algorithm? (4)
c) What are BLAST and FASTA? (4)

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3. a) State the data base structure of GenBank and how it can be used to make discoveries.
b) Give the importance of OMIM and SNP database (DbSNP). Describe briefly these databases. (5+5)

4. a) Give examples of protein-protein interaction databases and describe their usefulness in protein-protein interactions. (6)
b) How species 2000 database is different from ICTV database? (4)

BIOLOGY (20%)
5. Golgi generates two types of vesicle tshat are destined for lysosomes and plasma membrane. In what way the two types of vesicles differ from each other? Describe the mechanism by which these vesicles find and fuse with the right target. (4+6)

6. If Down’s syndrome occurs in 1 out of 700 births and Turner’s syndrome in 1 out of 5000 cases, answer the followingi. What are the chances that two cases of Down’s syndrome occur in one hospital on the same day? (3)
ii. If the number of births in a country is 3,50,00,000, how many cases of Down’s syndrome are likely to be recorded among the new born? (3)
iii. If Down’s syndrome and Turner syndrome are randomly distributed, what are the chances that the newborn will be found with both syndromes? (4)

Physical& chemical sciences: (20%)
7. a) Draw a peptide group and show where water molecules can be bound noncovalently. (4)
b) Between the two molecules, water and carbon dioxide, which one has a dipole moment? Is carbon-dioxide IR active? Give reason. (4)
c) Between electrostatic and van der Waals energ ies, which effect will be felt at longer distances? (2)

8. a) If the pKa of the ? amino group in lysine is 9.2, what will be the percentage of the lysine that will have a ? protonated amino group at a pH of 7.0 (4)
b) A molecule sho ws an absorbance of 1.00. The concentration of the solution is 2X10-5 ML-1. The measurement was done in a cuvette of length 2 cm (4)
1) What is the molar absorptivity?
2) What is % of light that reaches the detector?
c) The activation energy for the hydrolysis of sucrose is 107 kJmol-1 in the presence of H+. When the enzyme saccharase is added, the activation energy is 36 kJmol-1. What is the order of magnitude change in the rate of the reaction of the enzyme catalysed to the H+ catalysed reaction? (2)

9. b) Can the equation 3x + 4y - 2z = 6 be written in the form of –
(i) dot product of two vectors;
(ii) cross product of two vectors? If yes find the vectors and interpret their geometrical relation, if any. If not, why?
c) Find the roots of the quadratic equations: x2 -5x + 6 = 0
d) Find the area of the triangle formed by the x-axis, the y-axis and the line x +3y = 6. (3 +3+2+2 )
Find the stationary points of the following functions and determine their nature:
(i) x3 –12x +5 (ii) ex cos(x) (5+5)

IT: (20%)
11. Write a C or Perl or Java program to compute the transpose of a 3X3 matrix. A matrix and its transpose are shown below. (10)
12. Write a C or Perl or Java program to check if a given 3X3 matrix is symmetric. A matrix shown below is symmetric if A2=B1, A3=C1 and B3=C2. (10)