www.binc.scisjnu.ernet.in BINC Question Paper : BioInformatics National Certification

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Sample Question Paper for BINC :
OBJECTIVE TYPE : PAPER I
BioInformatics National Certification (BINC) Examination

Bioinformatics: (40%)
1. Which of these amino acids is “structurally” classified as being polar?
A. Phe B. Pro C. Ala D. Leu
2. What makes FASTA faster than NEEDLEMAN WUNSCH algorithm?
A. The processor speed of the computer B. Hash table lookup
C. Dynamic programming D. The scoring matrix used
3. How many edges meet at every branch node in a phylogenetic tree?
A. 1 B. 2 C. 3 D. 4
4. What is the difference between RefSeq and GenBank?
A. RefSeq includes publicly available DNA sequences
B. GenBank includes non redundant curated data
C. GenBank sequences are derived from RefSeq
D. RefSeq sequences are derived from GenBank

http://binc.scisjnu.ernet.in/sample_...ionPaper-I.PDF

6. The approach that can be used to predict the 3D structure of a protein which has no detectable sequence similarity with the available templates is
A. homology modeling B. comparative modeling C. fold recognition D. ab initio modeling
7. Which of the following can be determined using molecular mechanics?
A. Molecular orbital energies B. Minimum energy conformation
C. Electrostatic potentials D. Transition-state geometries
8. The Ramachandran plot is a
A. Phi-Psi scatter diagram. B. Phi-Psi correlation diagram.
C. Phi-Psi steric contour diagram. D. Phi-Psi energy diagram.

Biology : (20%)
9. The dominant allele R causes seeds of maize to be coloured where as the recessive allele r causes the seeds to be colourless. From the cross Rr x Rr, what fraction of the coloured seeds will be heterozygous?
A. 2/3 B. 1/2 C. 1/3 D. 1/4
10. Many genes involved in pathogenicity are located in defined continuous regions (“islands”) of the genome and have different GC content from other portions of the genome, suggesting that they have arisen through
A. horizontal gene transfer
B. gene duplication and subsequent mutation
C. protection from methylation
D. increase in the rate of mutation of successive GC pairs
11. Polycistronic mRNA refers to
A. mRNA which is transcribed by multiple RNA polymerases
B. mRNAs that are simultaneously translated
C. mRNA that is translated by many ribosomes simultaneously
D. mRNA with multiple open reading frames
12. Which of the following hybrids will be most stable?
A. AGTGTC TCACAG B. ATAGGC TATCCG C. GTTGGC CAACCG D. ATTGGC TTTCCG

Physical & Chemical Science (20%)
Most accurate mass with highest sensitivity in case of a protein is determined by
A. high resolution Mass spectrometer
B. electrospray ionization tandem Mass spectrometer
C. MALADI– TOF D. 2D Gel electrophoresis
Value of coefficient of kurtosis for a Normal distribution is
A. positive B. negative C. equal to one D. equal to three
A linear arrangement of three DNA nucleotides called a triplet contains four possible bases (A, C, G and T). How many different triplets are possible without ‘AT’ as first two letters?
A. 32 B. 48 C. 60 D. 64