www.daburresearch.in Dabur Research Foundation Delhi : Preclinical Coordinator

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Position Details - Preclinical Coordinator - Dabur Research Foundation

Position Code : PC/DRF

Position : Preclinical Coordinator - Dabur Research Foundation

Location : NCR

Functional Area : Preclinical R & D, DRF

Specific Attributes
Will be responsible for overall coordination of preclinical studies carried by DRF
Will work with the Project management team to understand client requirements for the proposed studies
Will work with technical Group leaders to ensure effective coordination of the pre-clinical studies
Will assist in leveraging of existing contract services and provide technical support for development of new services at DRF
Close interaction with QAU to ensure quality in the studies conducted by the technical teams

General Attributes
Knowledge of Cell Biology, toxicology, pharmacology, analytical & DMPK aspects of preclinical drug development
Ability to effectively coordinate the planning & execution of client driven preclinical studies at DRF
Ability to troubleshoot and provide innovative solutions for timely delivery on studies

Educational Qualification
Ph.D in Biology / Pharmacology or related Life Sciences field, with 3-4 years of experience in Preclinical CRO or Drug discovery focused Pharma sector

Skills
In depth understanding of the pre-clinical drug development process & regulatory guidelines
Keen ability to work effectively & creatively with teams

Desired
Should have work experience in preclinical CRO or Drug discovery industry

Minimum Years of Experience : 8

Apply Now : http://www.daburresearch.in/Post-Your-Resume.asp?id=10

About us :
Dabur Research Foundation (DRF) is an emerging high quality Contract Research Organization based in India, which provides Integrated Research Solutions in Pre-clinical Biology to national and international pharmaceutical, chemical and biotechnology industries. We excel in providing comprehensive range of services for pharmacological, biological and analytical testing of drugs and chemicals in vitro and in vivo.

Contact us:
R&D Centre
22, Site IV, Sahibabad
Ghaziabad - 201010
Uttar Pradesh, India
http://www.daburresearch.in

[Guest]

TIRUMALA. G. VARADARAJU, Ph.D. –
Email : varadaiitm2002 AT gmail.com
As a hardworking researcher, I look forward to reach an eminence by optimally exploring my
knowledge and skills to contribute efficiently towards the research and development activities in the
area of synthetic organic chemistry as well as medicinal chemistry.
Educational Qualification
Postdoctoral Research Fellow (Aug. 2010-till date)
National Tsing Hua University, Hsinchu, Taiwan, under guidance
of Prof. Reuben Jih-Ru Hwu
Doctor of Philosophy (PhD) : Synthetic Organic Chemistry, (Sep. 2004-June. 2010)
National Tsing Hua University, Hsinchu, Taiwan, under guidance
of Prof. Reuben Jih-Ru Hwu
Thesis : “Asymmetric Syntheses of Polymethylated Caffeic Acid Dimers and Trimers as Anti-HIV
Agents and Total Synthesis of Rosmarinic Acid”
Master of Science (Chemistry) : (Aug. 2001-Aug. 2003)
Indian Institute of Technology, Madras
Thesis entitled as “Lithium Intercalation into Sodium Zirconium Phosphate Materials"
Bachelors’ Degree : B.Sc (M.P.C) Osmania University, Hyderabad (June1997-July 2000)
Fellowships/Awards
Ph.D. Fellowship funded by National Science Council, Taiwan, R.O.C (2004 - 2010).
Graduate Aptitude Test in Engineering (GATE) 2003 Score : 88.57 percentile
Research Summary :
First Asymmetric Syntheses of Permethylated Caffeic Acids as Anti-HIV Agents. This part of
thesis developed a route for the asymmetric synthesis of methyl lactate and its antipode. Application
of the general protocol culminated in the asymmetric syntheses of both the antipodes of
permethylated rosmarinic acid, salvianolic acid D, salvianolic acid C, salvianolic acid A, and their
biological activity against HIV-1 virus replication was evaluated. Among them, permethylated (+)-
rosmarinic acid and (±)-salvianolic acid C were found to inhibit the replication of HIV-1RTMF (AZTresistant)
virus with IC50 values of 34 µM and 50 µM respectively.
2
MeO CHO
MeO
MeO
MeO
OMe
OH
R
O
MeO
MeO
OMe
OH
O
S
MeO
MeO
OMe
OH
O
4 Steps
4 Steps
4 Steps
O
OMe
O O
OMe
OMe
OMe
O
MeO
MeO
O
O
OMe
MeO
MeO
O
R OMe
R
OMe
OH
OMe
MeO R
MeO
OMe
O O
O
MeO
MeO
OMe
R
OMe
COOMe
OMe
O O
O
MeO
MeO
OMe
R
OMe
OMe
O
OMe
Pentamethyl Rosmarinic Acid
Permethylated Salvianolic Acid D
Permethylated Salvianolic Acid C Permethylated Salvianolic Acid A
3
Synthesis of Heptamethyl Lithospermic Acid. Herein, we have established the two different
routes for the synthesis heptamethyl lithospermic acid. In the first strategy, a modular, flexible, and
convergent route to the heptamethyl lithospermic acid along with its diastereomeric form has been
accomplished from 3,4-dimethoxybenzaldehyde in 11 steps. Second strategy, discloses the
alternative method for the synthesis of trans-cinnamic acid core of lithospermic acid and also
successfully applied for the synthesis of heptamethyl lithospermic acid. This synthetic route can be
applicable for asymmetric synthesis of heptamethyl lithospermic acid.
CHO
OMe
OMe O
OMe
O O
OMe
OMe
O
MeO
MeO
COOMe
OMe
R
Heptamethyl Lithospermic Acid
R
S
S
R
11 Steps
CHO
OH
OMe
OBn
OMe
Br
OMe
O
O
OMe
O O
OMe
OMe
O
MeO
MeO
COOMe
OMe
R
Heptamethyl Lithospermic Acid
S
S
R
R
6 Steps
5 Steps
Total Synthesis of Rosmarinic Acid and (R)-Oresbiusin A and B. This part of thesis presents the
total synthesis of polyphenolic acids which exploits tert-butyldimethylsilyl (SiMe2t-Bu) as an ideal
protecting group. Total synthesis of (±)-rosmarinic acid was accomplished in 7 synthetic steps from
3,4-dihydroxycinnamic acid with 42% overall yield. In addition, developed an efficient, convenient
route for the total synthesis of (R)-oresbiusin B through a linear approach from 3,4-
dihydroxycinnamic acid in 6 steps with 64% overall yield. Furthermore, efficient and flexible routes
were established for the syntheses of orthogonally protected skeleton of salvianolic acid C and
salvianolic acid D.
4
OH
CHO
OH
9 Steps
OSiMe2t-Bu
O O
O
t-BuMe2SiO
t-BuMe2SiO
OMe
OBn
COOMe
R
Salvianolic Acid D Derivative
CHO
OH
OH
6 Steps
O
OBn
O O
OSiMe2t-Bu
OSiMe2t-Bu
OMe
O
t-BuMe2SiO
t-BuMe2SiO
R
Salvianolic Acid C Derivative
OH
O
HO
HO
O
O
OH
OH
(± )-Rosmarinic Acid
OH
O
HO
HO
7 Steps
Caffeic Acid
OH
O
MeO
HO
O
OMe
O
HO
HO
O
OMe
R OH
Ferulic acid
(R)-Oresbiusin B
6 Steps
Highlights :
Developed skills in multistep, multiscale organic synthesis.
Developed new methodologies in organic synthesis.
Experienced with multinuclear NMR, FTIR, UV-VIS, and HPLC.
Proficient in carrying out independent and collaborative research.
Ability to write scientific research articles
5
Publications :
1. First Asymmetric Total Syntheses of (+)-Rosmarinic Acid and Permethylated Caffeic
Acids as Anti-HIV Agents. Jih Ru Hwu,* Tirumala G. Varadaraju, Ibrahim S. Abd-
Elazem, and Ru Chih C. Huang* (resubmission under progress).
2. First Total Synthesis of Oresbiusin A and B Their Antipodes and Racemates : Configuration
Revision and Anti-HIV Activity. Jih Ru Hwu,* Tirumala G. Varadaraju, Ibrahim S. Abd-
Elazem, and Ru Chih C. Huang* (manuscript in preparation).
3. Concise Synthesis of Heptamethyl Lithospermic Acid. Jih Ru Hwu,* Tirumala G.
Varadaraju (manuscript in preparation).
Conference Presentations :
1. “Synthesis and Applications of Benzo[b]furans to Functional Molecules” Tirumala. G.
Varadaraju and Jih Ru Hwu* NTHU (Taiwan)–TIT (Japan)-2005 Workshop on Organic
Chemistry for Junior Chemists- February 25–27, 2005.
2. “Asymmetric Formal Total Synthesis of (+)-Rosmarinic Acid” Tirumala. G. Varadaraju
and Jih Ru Hwu* NTHU (Taiwan)–KAIST (South Korea)-2009 Junior Chemists
Workshop-February 13–15, 2009.
Instruments Handled :
Mercury 400 MHz NMR; Agilent 6890N GC MS; GC 2014 Shimadzu; HPLC (Waters 515).

[Guest]

Pallavi Dubey
Email id : dubey.pallavi04 AT gmail.com , pallavid_2006 AT rediff.com
Career Objective :
Seeking a position in Monitoring or CDM department in a Clinical Research organization to meet challenges and be vibrant force & core strength of the organization.
About myself :
I am energetic, goal oriented and. I plan my work and finish it as soon as possible. I always work out on my faults and try to improve those areas. I am eager to learn and can cope up with new environment and can adapt very fast. I regard myself as being creative, motivated, hard working. I have a certain goal in my life and I will move forward with my full potential and knowledge.
Work Experience :
Worked as a Dietician in Inspirations Healthcare Private Ltd. (from April 2009 to April 2011)
Educational Qualifications :
S.No Degree/ Certifications
College/School Board/University Year of Passing Percentage/Grade
1 Advance Diploma in Clinical Research Clinotek India Bangalore University 2011 (pursuing) NA
2 P.G diploma in Dietetics SAARC Educational Academy Affiliated to S.N.D.T Women’s University, Mumbai, Nagpur 2008 “A” grade
3 B.Sc. Biotechnology Kamala Nehru College Nagpur University 2007 IInd class
4 XIIth Dhanbad Public school CBSE board 2004 Ist class
5 Xth Dhanbad Public School CBSE board 2002 Ist class
Clinical Research Domain Knowledge :
- Basics of ICH-GCP Guidelines
- Basics of 21-CFR-PART-11
- Theoretical understanding of Clinical Data Management
- Basic knowledge of Pharmacovigilance
- Basic understanding of Clinical Operations
Areas of Interest :
- Clinical Research Management
- Clinical Data Management
- Site Management
- Pharmacovigilance
- Regulatory Affairs
- Document Management
Computer Skills :
- Operating system : Win98/NT/2000/XP/VISTA/
- Languages Known : Certification in C language
- MS office : MS-Word, Power Point, Excel
- Internet Usage
Soft Skills :
- Fast learning ability
- Effective communication skills
- Self motivated
- Deterministic
- Team working
- Hardworking
- Self confidence
Achievements and Professional Activities :
- Active participant in organizing forums, paper presentation, seminars, cultural activities, attended workshop
- One month internship as a trainee dietician in “Avanti Institute of Cardiology”, Dhantoli, Nagpur
- One month internship as a trainee dietician in “Diabetes Care & Research Centre” Ramdaspeth, Nagpur
- Three months community internship from 5th may to 31st July, 08
- Three months internship as a trainee dietician at “Indraprastha Apollo Hospital”, Sarita vihar, New Delhi from 5th Aug to 5th Nov 2008
- Attended National Conference of “INDIAN DIETETIC ASSOCIATION” at Kottayam in 2007, and at Hyderabad in 2008
Projects Undertaken :
- Genzyme Biosurgery :
In this project different techniques were used involving different genes & enzymes in the bio-surgical processes with all modern & advance methods.

- Nutritional assessment of food habits in corporate sector executives :
In this project detailed information and survey was done to identify the food habits of
Corporate and Executives which play an important role in their work efficiency and performance.
- Role of antioxidants in degenerative disease :
In this project different foods containing antioxidants and their specific roles in reducing diseases were described.
- ‘Acid Ash’ and ‘Alkaline Ash’ diets :
In this project different categories of foods were described according to their acidic and alkaline nature.
- Case study of patients :
During hospital internship period providing detailed information regarding their diagnosis and dietary pattern.