Pall India Pvt Ltd Bangalore : Biopharmaceutical Downstream

[mskavi]

Pall India Pvt Ltd. Bengaluru/Bangalore : Downstream Specialist - Biopharmacutical Division

Designation: Downstream Specialist - Biopharmacutical Division
Experience: 5 - 10 Years
Location: Bengaluru/Bangalore

Job Description:
1) He should successfully position various Pall downstream Technologies in the Customer process
2) He will evaluate Pall technologies, products at customer R&D and process development stage
3) He will conduct scale-up studies for the customers and ensure the process is established on Pall products
4) He will ensure that the Scale-up results are translated in to optimum System Design by working in coordination with Systems Manager
5) He will be responsible for FAT along with the Systems Manager and PASS
6) He will perform the SAT along with PASS and Systems Manager
7) Once the systems are delivered he will work with the customer on Optimizing the process.
8) He will assist and work with the lab specialists in the Pall pilot lab Facility
9) He will be involved in customer training programs on Downstream Processing.

Desired Candidate Profile:
1) Candidate should be having B.Tech/ M.Tech Biotechnology or Biochemical Engineering or M.Sc Biochemistry or Molecular Biology or Biotechnology.
2) S/he should be conversant and hand's on with technologies like SDS page, FPLC, HPLC, UV Spectrophotometer, Chromatography (both resins and column packing), TFF , Ultracentrifugation and various methods/techniques of protein estimation.
3) Experience in the Biological, vaccine and or virus Research laboratory involved in Downstream processing from Process Development to scale up of biological derivatives and or Recombinant Proteins.

Address:
Pall India Pvt Ltd
6th Floor, Sumer plaza, CTC 419, Marol Maroshi
Road, Andheri(E),
MUMBAI,Maharashtra,India 400059
Phone: +91 - 22 - 6799 55 55

Pall India Pvt. Ltd.
No. 1, Sarakki Industrial Layout
Ring Road, JP Nager 6th Phase
Bangalore 560078
Phone: +91 80-40164100

Website: http://www.pall.com
Keywords: downstream, DSP, Lab, Biopharma application, biotech, bio - tech, scientist

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[Guest-IJT]

Certificate course

- Medicinal Plant Tissue Culture, Madras University.

Technical Skills

Operating System : Windows, Ms Office.
Know to operate : Centrifuge, Spectrophotometer, Electrophoresis,
PCR, Elisa reader, SDS-PAGE,
Transformation techniques,
Tissue culture techniques,
Chromatographic techniques.


Paper Presentation And Awards

Paper Presentation : Won third prize in S.I.V.E.T College, Gowrivakkam
(stem cell research)

Participated in intracollege competition (Gene therapy)

INPLANT TRAINING PROGRAMME

Title SERENO
Type Communication skills
Duration May’08 to June’08
Location aavin Tamilnadu Co-operative Milk Producers’ Federation Limited,
Sholinganallur.

Description:

The main objective of this training program is to improve our communication skills with others in our field.


Project #1

Title APREA
Type Antimicrobial activity and Phytochemical screening of Catharanthus roseus
Duration Dec’08 to Mar’09
Location Prince Shri Venkateshwara Arts and College, Chennai.

Description:

The main objective of this project is to get remedy for the diseases of the most opportunistic pathogen including bacteria and fungi with the help of herbal source.
Catharanthus roseus is commonly known as Periwinkle, Nithyakalyani, and Sudukatumalli.The antibacterial and antifungal activity of the plant was carried out against most opportunistic pathogens. Phytochemical screening and chromatographic technique (TLC) was performed.

[Guest]

i am msc in microbiology and applying for biopharmaceutical downstream in pall india pvt ltd i have a good academic career and good laboratory skill can carry out job with perfection

[manojreddyvindyala]

____ Manoj Kumar v. j__________
manojvindyala AT gmail.com
OBJECTIVE : Desired to work in process and development where my experience and skills can be utilized for the development of your esteemed organization.
WORK EXPERIENCE :
May 2009 – Till date Production Executive, Virchow Biotech pvt. Ltd, India
(ISO 9001, UKAS, NQA certified organization)
http ://www.virchows.com/home1.htm
AREAS OF EXPERTISE : Protein purification and Documentation of In process records, BMRs and SOPs, and validation of process and equipments and cGMP guidelines.
HANDS ON EXPERIENCE :
- Purification of proteins from E.coli (Expressed in the form of Inclusion bodies)
- Lysis methods, Protein Refolding.
- Small-scale production.
- Ultra filtration, Diafiltration.
- Handling of chromatographic methods like Affinity Chromatography, Reverse phase chromatography, Ion exchange chromatography.
- Columns (fine line,BPG,XKcolumns)
- Formulations (Injectables)
TECHNICAL SKILLS :
- CELL CONCENTRATION AND INCLUSION BODY WASHINGS using hollow fiber catridge
- LYSIS METHODS (homogenization, dynomill, French press)
- CENTRIFUGATION (Sorvall, Remi)
- HPLC ( AKTA Purifier, AKTA Pilot)
- Ultra filtration / Diafiltration (Sartorius)
- Filter integrity testing. (using sartocheck)
- Lyofilization(LSI)
SKILLS :
- Major Action planning, Analytical and logical thinking, Managing and
Interpreting information, Team Work and collaboration.
- Minor Adaptability,Empathizing and Managing and Organizing, Questioning, listening, Viewing and spatial sense.

- Team work Able to adjust to different team member attitudes and the same
time being responsible to the assigned job.
- Communication Oral communication skills expressed in presentations and in
talking to general public.
- Computer skills Knowledge and experience of MS office, MS Access, Using
email and internet.
EDUCATIONAL QUALIFICATION :
Institute/university Degree Year of
Passing % of marks
Madanapalli institute of technology & science, MADANAPALLI. B.Tech. Biotechnology 2008 70.72%
Bapatla polytechnic college,
BAPATLA. Diploma in Biotechnology 2005 73.66%
Balayesu junior College,
HINDUPUR. 12th (state board) 2003 80.80%
Sri Saraswathi vidya mandir,
HINDUPUR. 10th (State board) 2001 77.16%

[Guest]

Noopur Saxena

Email : noopur.saxena1 AT gmail.com

EDUCATION

Degree : B-Tech In biotechnology
University : Institute of Engineering and Technology, Bundelkhand University, Jhansi
Year of passing : 2006
CGPA : 70%
Degree : HSC (UP Board)
University/School : Dr. V. S. E. C, Sharda Nagar , Kanpur (U.P.),
Year of passing : 2000
CGPA : 72%
Degree : SSC (UP Board)
University/School : Dr. V. S. E. C, Sharda Nagar , Kanpur (U.P.),
Year of passing : 1998
CGPA : 73%
WORK EXPERIENCE
- Reliance Life Sciences Pvt Ltd working as Research Scientist, April 2009- Present.
- Worked as Research Fellow with Reliance Life Sciences, Dec 2006-April 2009
Job Responsibilities :
- Process Design, Development, Method Developments (HPLC, UPLC, and FPLC) and DSP Scale up (Up to 640 Liters) of several Recombinant Therapeutic Drugs (Neurology, Oncology (working on all Blockbuster Monoclonal Antibodies)
- Worked on Bacterial & Mammalian Expression systems with hands on experience on all different types of chromatography& Bio Physical Techniques for characterization of proteins.
- Technical write ups and reports on process development to seek approval from governing bodies (RCGM, FDA, DCGI, EMEA) for Pre-clinical, Clinical studies and Commercial Scale Manufacturing.
- Process validation, QA-QC Documentations, Technology transfer to production group which involves performing trial runs in cGMP plant, training personnel involved in commercial production and providing technical support.
- Production Planning, Manufacturing of biosimilar products under cGMP (DCS, SCADA platforms) and ICH guidelines.
- Writing patents, Publications, Dossiers for Regulatory Bodies and Presentations.
- Technical coordinator for Reliance School of Life Sciences.
Projects Accomplished :
Process Development & Characterization of IL1RA
This protein is developed in periplasmic space of E Coli. Chief strategy was protein extraction without total disruption of cell which would have further complicated the purification procedure. Purification process developed is one of the shortest and most economical processes . Purification process included extraction, ion-exchange chromatography, hydrophobic interaction chromatography followed by final concentration by TFF. Process development and optimization is complete.
Process Development & Characterization of Recombinant Interfreon beta 1a
Current status Product has been recently launched in market by the brand name Relibeta.
Protein was expressed extracellularly in CHO cells. Purification process included affinity chromatography, gel filtration chromatography and ion exchange chromatography. Extensive characterization have been done using various biophysical techniques.
Down stream processing and Characterization of various Monoclonal Antibodies
Current status Process has been optimized for pilot scale production
Devised strategic Platform Process for manufacturing of Biosimilar Monoclonal Antibodies (mAbs) to ease technical difficulties in scale-up works.
Characterization was done employing peptide map analysis, host cell protein analysis, Protein A leaching estimation, Bioactivity analysis for these proteins
Process Development & Characterization of Various Glycosylated proteins
Some proteins exists in the form of many glycoisoforms and therefore purification of such proteins become a challenge. The protein has been purified using different chromatographies. Process development has been successfully accomplished with all characterization done including Sialic acid estimation, Glycan analysis, Molecular weight determination, IEF gels and Peptide map analysis.
Techniques Known :
Chromatographic Technique :
Reverse Phase Chromatography, Hydrophobic interaction chromatography, Gel Filtration, Ion exchange Chromatography, Affinity chromatography.
Filtration Technique :
Cross flow/TFF, Nano Filtration and Sterile Filtration.
Spectrometric Technique
Estimation of protein using spectrophotometeic analysis.
Bradford methods.
Sialic acid estimation
Carbohydrate Analysis
Biochemical and biophysical methods
SDS PAGE, Immunobloting, Isoelectro Focussing, ELISA for bioactivity, ELISA for determination of antibodies generated against proteins in Serum samples , HCP content present in proteins and Protein A ELISA.
Awards and Achievements :
- Successfully completed Process Development ground work and was involved in every progress of several Therapeutic drugs, many of which are in market.
- Devised strategic Platform Process for manufacturing of Biosimilar Monoclonal
Antibodies (mAbs) to ease technical difficulties in scale-up works.
- Participated in International Symposium on “Recent Advances In Biopharmaceuticals”, conducted in Reliance Life Sciences, Pvt Ltd
- Presented poster on Charge Heterogeneity based purification in Erythropoietin and Darbepoetin alpha in therapeutic Proteins retreat at Reliance Life Sciences.
- Awarded with Best Employee of the year with Reliance Life Sciences for the year 2011

[Guest]

can i get the HR address? i need to apply for internship!