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Formulation Executive Mumbai : VVF Ltd
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[QUOTE=Guest;141684]KRANTHI KUMAR. MARKA [b]Email [/b]: kranthikumar_9 AT yahoo.com CAREER OBJECTIVE I would like to utilize my skills, abilities and my strengths for an all-round growth of myself and for the betterment of organization. EDUCATIONAL SUMMARY - Master of Pharmacy in Pharmaceutics, G. Pulla Reddy College of Pharmacy, Osmania University, Andhra Pradesh, with an aggregate of 66.3% in 2010. - Bachelor of Pharmacy from Vaagdevi College of Pharmacy, Kakatiya University, Andhra Pradesh, with an aggregate 66.8% in 2008. - Bi.P.C from Board of Intermediate Education Andhra Pradesh, with an aggregate of 62.5% in 2001. - SSC from Board of Secondary Education, Andhra Pradesh with an aggregate of 64.67% in 1999. INTERESTED AREAS RA / FR&D / QA at Formulation operations. [b]Project [/b]: Formulation and Evaluation of Ibuprofen Topical Gel: A Novel Approach for Penetration Enhancement [b]Description [/b]: [b]The main aim of this research work was made to increase the therapeutic effectiveness of ibuprofen, by increasing the transdermal permeation, via solid dispersion incorporated in gel using 2- hydroxy propyl beta cyclodextrin as carrier and carbopol 941 as gelling agent. The optimized formulation was incorporated into gel and was compared with various penetration enhancers like, isopropyl myristate, phospolipon 80H, and menthol. The formulation with 1 [/b]:0.5 (drug : 2- hydroxy propyl beta cyclodextrin) containing menthol as permeation enhancer gave better results with partition coefficient 1.28, 96.5% of drug release and solid dispersion of ibuprofen produced release of 98.21 % drug release is achieved in 8 hours. The optimized formulations were further studied for ex-vivo permeation through the rat abdominal skin and anti inflammatory activity. In ex-vivo studies among all the optimized formulations SDIB and SDIBM5% formulations gave 94.3% and 92.36% drug release within 24hrs, when compare to other formulations. The percentage inhibitions of the oedema formation by the gels were in the range of 18.32% to 67.96% and the maximum inhibition was shown by SDIB formulation. SDIB formulation incorporated in gel produced better results than other formulations prepared with permeation enhancers. ACHIEVEMENTS Qualified PGECET with state 19th rank (2008). Playing member of cricket team from School level to PG. PERSONAL SKILLS Versatile individual with good learning curve, Enthusiastic, Dedicated and result oriented team member having leadership qualities with good communication and interpersonal skills. Actively participates in many national and international symposia. Highly motivated, resourceful and willing to acquire responsibility. CONFERENCES ATTENDED&SEMINARS PRESENTED____________________ Attended National Level seminar on “Recent Advances in Pharmaceutical Research” held at G. Pulla Reddy College of Pharmacy, Hyderabad. Presented a poster on “Formulation and Evaluation of Ibuprofen Topical Gel: A Novel Approach for Penetration Enhancement” at second International Conference on Current status and future perspective in pharmaceutical sciences.[/QUOTE]
