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[QUOTE=Guest;110861]RESUME
Dr. SADASHIVA C. T
 shiva1hassan AT yahoo.co.in / sada1hassan AT yahoo.co.in 
[url]www.cmpr-avs.com[/url]
[b]1. Ph. D. in Chemistry [/b]: University of Mysore (2007)
[b]Title of the Thesis [/b]: “Synthesis and Pharmacological action of Piperazine Derivatives and non ester-analogous of Arecoline to Alzheimer’s disease”. (Research guide: Prof. K.S Rangappa, M.Sc, Ph.D, D.Sc, FRNASc, Vice Chancellor, Karnataka State Open University, Mysore)
2. M.Sc., in Bio Science (1997) 
Department of Bio-Science, University of Mysore, Hemagangotri Hassan- 573201
3. B.Sc, 1994 
Govt Science Collage Hassan, University of Mysore, Mysore-06
[b]Additional Qualification [/b]: 
1. A certificate course on “Care, Breeding and Management of Laboratory Animals” from Central Animal Research Facility, at NIMHANS, Bangalore.
[b]Experience [/b]: 
1. Quality Control (QC) Officer in Charak Pharmaceuticals Company Somanahally Ind.Area, Mandya Dist. Mandya.Karnataka, India for five years (1997-2003) 
2. Research Scholar (2003-2007) University of Mysore 
Involved in the synthesis and characterization of piperazine & arecoline derivatives using IR, NMR and X-ray crystallography. Pharmacological properties and efficacy was checked by acetyl cholinesterase and receptor binding studies using animal behavioral models (T maze, Plus maze and Passive avoidance).
3. Senior Scientist (2007- Present)
Engaged in standardization of medicinal plants, extraction, isolation, characterization and quantification of biomarkers using different analytical technique (TLC, HPLC, HPTLC, GC, NMR, LCMS, GCMS and column chromatography) and validation of medicinal plants through in vivo and in vitro models (Antidiabetic, antiinflamatory, hypolipidemic, Alzheimer’s disease and anticancer).
4. New drugs developed – 6
5. M.Sc Project Training -12
6. M.Phil project --3
7. Number of patents---2
8. Visiting Scientist School of Conservation and Biological Science, University of Kwazulu Natal, Durban South Africa. July 2010 to Aug 2010. 
RESEARCH SKILLS 
- Enzyme inhibition study
- Animal model experiments 
- Radioligand Receptor Binding studies 
- ELISA
- Antimicrobial activity 
- Antidiabetic activity 
- Animal cell culture work 
- Drug Standardization 
- Extraction, isolation, distillation, structure determination, and quantification of phytochemicals (bio-markers)
INSTRUMENTS HANDLED
1. T maze, Plus maze and Y maze ( Behavioral model Experiments) 
2. HPLC ,HPTLC,,GC,GC-MS,,LCMS,FTIR,Rotavapor (BUCHI)
3. Spectrophotometer
4. Column chromatography 
5. TRI-CARB 2100TR, Liquid Scintillation Analyzer (Packard Bioscience Company)
6. Millipore MultiScreen 96 wells filter plates for receptor Radioligand binding assay
[b]List of Publications [/b]:
1. C.T. Sadashiva, J. N. Narendra Sharath Chandra, K. C. Ponnappa, T. Veerabasappa Gowda and Kanchugarakoppal S. Rangappa., 2006, “Synthesis and Efficacy of 1-[bis(4- fluorophenyl)-methyl]piperazine Derivatives for Acetylcholinesterase Inhibition, as a Stimulant of Central Cholinergic Neurotransmission in Alzheimer’s Disease” Bioorganic & Medicinal Chemistry Letters 16, 3932–3936..
2. C.T. Sadashiva, J.N. Narendra sharath chandra, C.V. Kavitha, A. Thimmegowda M.N. Subhash and Kanchugarakoppal S. Rangappa. Synthesis and Pharmacological Evaluation of Novel N-alkyl/aryl Substituted Thiazolidinone Arecoline Derivatives as Muscarinic Receptor 1 Agonist in Alzheimer’s Dementia Models. European journal of Medicinal chemistry (2009) 1–7 
3. C. T. Sadashiva, S. Naveen, J. N. Narendra Sharath Chandra, M. A. Sridhar, K. S. Rangappa and J. Shashidhara Prasad. 2006, “Crystal Structure Analysis of a Bioactive Piperazine Analog 1-[bis-(4-fluorophenyl)-Methyl]-4-methane sulfonyl piperazine”, Molecular crystals and Liquid Crystals.469, 89-97
4. C.T. Sadashiva , P. Sharanappa , A.B. Remashree , P.S. Udayan , and Indira Balachandran Chemical Composition and Antibacterial Activity of Essential Oil From Bark of Pittosporum Dasycaulon Miq. World Academic Science Journal 2010(Inpress)
5. J. N. Narendra Sharath Chandra, C. T. Sadashiva, C. V. Kavitha and K. S. Rangappa. 2006, “Synthesis and In-vitro Antimicrobial Studies of Medicinally Important Novel N- alkyl and N-sulfonyl Derivatives of 1-[bis(4-fluorophenyl)- methyl]piperazine”, Bioorganic & Medicinal Chemistry 14, 6621-6627
6. J. N. Narendra Sharath Chandra, K. C. Ponnappa, C. T. Sadashiva, B. S. Priya, B. L. Nanda, T. Veerabasappa Gowda, B. S. Vishwanath, and K. S. Rangappa, 2007, “Chemistry and Structural Evaluation of Different Phospholipase A2 Inhibitors in Arachidonic Acid Pathway Mediated Inflammation and Snake Venom Toxicity”, Current topics in medicinal Chemistry. 7, 787-800.
[b]7. S. B Benaka Prasad., Y. C Sunil Kumar., C. S Ananda Kumar., C. T. Sadashiva, K Vinaya and K. S. Rangappa. 2007 “Synthesis of Novel N- Methyl-1,2,5,6-tetrahydropyridine-3- Derivatives by Suzuki Coupling [/b]: As Acetylcholinesterase Inhibitors”, The Open Medicinal Chemistry Journal. 1, 4-10. 
8. C. V. Kavitha, S. L.Gaonkar, J. N. Narenrda Sharath Chandra, C. T. Sadashiva, K. S. Rangappa. 2007 “Synthesis and Screening for Acetylcholinesterase Inhibitor Activity of Some Novel 2-butyl-1,3-diaza-spiro [4,4]non-1-en-4-one Derivatives of Irbesartan key Intermediate’’, Medicinal Chemistry.15, 7391-7398.
9. K. S. Rangappa, J. N. Narendra Sharath Chandra, C. T. Sadashiva and S. B. Benaka Prasad. 2006, “Designing Arecoline Analogues as M1 Receptor Stimulant to Treat Alzheimer’ Dementia”, my SCIENCE. 1(1), 19-42.
10. J. N. Narendra Sharath Chandra, C. T. Sadashiva, C. V. Kavitha and K. S. Rangappa, 2007. “Different Susceptible Genes in Alzheimer’s Disease”, my SCIENCE.2(1),1-12.
[b]11. Subban Ravi, C.T. Sadashiva, T. Tamizmani, T. Balasubramanian, M. Rupeshkumar, Indira Balachandran, 2009 “In vitro glucose uptake by isolated rat hemi-diaphragm study of Aegle marmelos Correa root” Bangladesh J. Pharmacol; 4 [/b]: 65-68.
12. G. V. Srinivasan, C. T. Sadashiva, Neethu George, and Indira Balachandran “Chemical Compounds in Biophytum reinwardtii and their antioxidant Potential”Journal of Tropical Medicinal Plants. Vol 9 No 2
[b]13. Kumar CS, Vinaya K, Chandra JN, Thimmegowda NR, Prasad SB, Sadashiva CT, Rangappa KS. Synthesis and antimicrobial studies of novel 1-benzhydryl-piperazine sulfonamide and carboxamide derivatives. Journal of Enzyme Inhibition and Medicinal Chemistry. 2008 Aug; 23(4) [/b]: 462-9.
14. Sunil Kumar Y. C. Malviya Manish, Narendra Sharath Chandra J. N. Sadashiva C.T. Ananda Kumar C. S, Benaka Prasad S. B, Prasanna D. S, Subhash M. N, Rangappa K. S. “Effect of novel N-aryl sulfonamide substituted 3-morpholino arecoline derivatives as muscarinic receptor 1 agonists in Alzheimer's dementia models” Bioorganic & Medicinal Chemistry, 2008, vol. 16, pp. 5157-5163 
15. C.T. Sadashiva, P. Sharanappa, S. Ravi, A. Thimmegowda and Indira Balachandran, 2009 “Quantitative Determination of And Phytochemical Investigation Of Essential oil of Orthosiphon Diffuses” Journal of Essential oil Research (Inpress) 
16. C.T. Sadashiva, P. Sharanappa, P.M. Viji, P. Abhiramasundari, S.V. Soundariya and Indira Balachandran, 2009 “Antibacterial, Antioxidant Activity and Phytochemical Screening in Leaves of Traditional Medicinal tree Buchanania axillaris (Desr.) Ramam” Journal of Ethanopharmacology (Submitted) 
17. C.T Sadashiva, Keshor, S. Ravi, C.V Kavitha, Sathees Raghavan, Indira Balachandran, 2009 “The antiproliferative agent 25-Hydroxy-stigmasterol Isolated from Costus Pictus leaves” Phytochemistry (Submitted)
[b]Conferences / Seminars / Symposia attended [/b]: -
1) Participated in the 19th Indian Council of Chemist (ICC Conference), December 21 to24th 2001. Mysore 
2) Participated and poster presentation in National Symposium on Bio Organic Medicinal Chemistry, University of Mysore, Mysore, October-7 to 9, 2005.
3) Participated in the Joint International Conference on Advances in Organic Chemistry and Chemical Biology (AOCCB2006) JANUARY 11-12-2006
4) Participated in the 19th Indian Council of Chemists (ICC Conference), December 27th to 29th 2006. Mumbai.
5) Participated in the Indo-Canadian Symposium Medicinal Plants and Functional Foods in the Management of Diabetes, obesity and Cardiovascular Disease March 2008 in Aurangabad 
6) Participated in the National Conference on Recent Trends In Plant Science February 2008 Bangalore.
7) Participated in the 1st International Euro-India Conference on Holostic Medicine (ICHM) August 21-23,2008 Kottayam, Kerala
8) Participated in the 1st International Conference 4th global summit on Medicinal and Aromatic plants, Kuching, Sarawak, Malaysia Dec-1-5,2009[/QUOTE]

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